The bandit Pratt, looking for Tim, who is responsible for the death of his two sons, attacks a caravan killing all the passengers. Harry, the vagabond, after having robbed the dead, casually meets Tim and they become friends. Running away together from Pratt, they reach Harry's farm, but their hiding place is soon discovered.

Sartana, bounty hunter and gunfighter, witnesses the robbery of a shipment of gold. He finds his way into town where he meets with a lot of suspicious stares from the locals. He also meets with Samuel Spencer, who seems to own the company in this company town. The gold shipments are being stolen, so Spencer agrees to hire Sartana to protect the next gold shipment. Numerous dull-witted villains make attempts on Sartana's life, but he survives. Eventually, Sartana's nemesis Sabbath (he of the white coat and parasol) rides into town. With a showdown inevitable, Sartana and Sabbath square off to settle the score.

After witnessing a brutal massacre, the legendary hero Sartana is ready to do some investigating. Almost everyone in the tiny town of Indian Creek seems eager to buy up the property left behind by the murder victims, and one of them could well be behind the killings. The sheriff himself is not above suspicion, so Sartana must uncover the culprit all on his own.