A group of poachers provoke the fury of a great white shark. After killing the poachers, the shark sets its sights on a group of friends celebrating their university graduation on a yacht. A life-and-death struggle on the open water ensues.

The film revolves around a shady factory that secretly digs up graves and unearths a two-headed python. Unlike previous snake thrillers where humans actively invade the rainforest, this time, the snakes descend en masse to launch a preemptive attack on a human settlement. Security captain Li Mingjun (Wu Tingye) and his apprentice Xie Feng (Jin Long) watch the hunt from a surveillance room to lure out the two-headed python. They then collude with factory manager Zhao Yongmin (Xu Shaohang) to transport sick pigs and instruct butcher Zhang Dawen (Li Long) to trap the python with a live human. Female forklift driver Xia Qing (Yang Lei) teams up with her fellow worker Wang Siyan (Chen Xinzhe) to fight against the forces of greed, ultimately shedding a venomous venom with maternal love.

利欲熏心的地产商为了开发蛇王岛，重金收买以金老四（王洪千 饰）为首的黑市捕蛇团伙，企图登岛扫清蛇患。为了印证泰坦巨蟒存在的传说，身为蛇王后人的陈峥（刘林城 饰）联手动物保护专家周晓晓（邵芸 饰）与金老四展开搏命厮杀，而蛇王岛上发生的一切，不断挑战着人性的最后底线……