When a small town doctor buries his twin brother, a practitioner of the black arts, he believes him dead; but subsequent events force him to realize that his brother has, in fact, returned from the dead as a vampire and is seeking revenge on the doctor, who had killed him in self-defense.

On the night express train from Los Angeles to San Francisco everyone’s a suspect when a jewelry magnate is found stabbed to death and an escaped killer is feared on board. It’s up to newspaper reporter Jimmy Hawley (Ben Lyon) to unravel the secrets of the motley group of passengers and find the killer before he strikes again in this tense and atmospheric whodunit.

Working in Dr. Cranley's laboratory, scientist Jack Griffin was always given the latitude to conduct some of his own experiments. His sudden departure, however, has Cranley's daughter Flora worried about him. Griffin has taken a room at the nearby Lion's Head Inn, hoping to reverse an experiment he conducted on himself that made him invisible. But the experimental drug has also warped his mind, making him aggressive and dangerous. He's prepared to do whatever it takes to restore his appearance.