A retired FBI serial-profiler joins the mysterious Millennium Group, a team of underground ex-law enforcement experts dedicated to fighting against the ever-growing forces of evil and darkness in the world.

据福斯电视部门老大加里·纽曼透露，新一季《X档案》可能因主演档期问题，延后至2018年底或2019年播出。但有望由上季的6集扩充至10集。作为经典剧集，《X档案》一直有着一批忠实粉丝。 即使在停播了14年后，于2016年初播出了全新的故事，首集便吸引到1350万观众收看。

谁也不曾想过，七十年前那期神秘的罗斯威尔事件，时至今日仍对全体人类产生着如此巨大的影响。并且鲜少有人窥见真相的全貌，即使它就在那里。某天，过着颓废生活的前联邦探员福克斯·穆德（大卫·杜楚尼 David Duchovny 饰）以及他最为信赖的搭档——正在某某教会医院担任医师的丹娜·斯科莉（吉莲·安德森 Gillian Anderson 饰）重新聚在一起。原来一档旨在揭露政治黑幕节目的主持人找到他们，希望二人披露政客利用外星人来控制人类的真相。以此为契机，关闭已久的X档案重新开启。一度对各种离奇事件失去信心的穆德，在斯科莉的陪伴下重新踏上征程。
而这一路上，层层隐藏起来的真相以及人类可怕的未来，将相继呈现在他们的眼前……

The first season introduced main characters of the series, including Fox Mulder and Dana Scully who were portrayed by David Duchovny and Gillian Anderson respectively, and recurring characters Deep Throat, Walter Skinner and The Smoking Man. The season introduced the series' main concept, revolving around the investigation of paranormal or supernatural cases, known as X-Files, by the Federal Bureau of Investigation; it also began to lay the groundwork for the series' overarching mythology.

Initially influenced by Kolchak: The Night Stalker and The Twilight Zone, series creator Chris Carter pitched the idea for the series to Fox twice before it was accepted for production. The season saw the series quickly gaining popularity, with ratings rising steadily throughout its run; and garnered generally positive reviews from critics and the media. It helped to make stars of its two lead roles, and several of its taglines and catchphrases have since become cultural staples.

Mulder and Scully are called back to duty by the FBI when a former priest claims to be receiving psychic visions pertaining to a kidnapped agent.