一对白天卖冰激凌的姐妹花，真实身份却是手持大枪打击犯罪的悍女，当他们的老爹被一群恶人绑架后，这对姐妹花大开杀戒……

Ex-Federale agent Machete is recruited by the President of the United States for a mission which would be impossible for any mortal man – he must take down a madman revolutionary and an eccentric billionaire arms dealer who has hatched a plan to spread war and anarchy across the planet.

After being set-up and betrayed by the man who hired him to assassinate a Texas Senator, an ex-Federale launches a brutal rampage of revenge against his former boss.

Austin's hottest DJ, Jungle Julia, sets out into the night to unwind with her two friends Shanna and Arlene. Covertly tracking their moves is Stuntman Mike, a scarred rebel leering from behind the wheel of his muscle car, revving just feet away.

Two doctors find their graveyard shift inundated with townspeople ravaged by sores. Among the wounded is Cherry Darling, a dancer whose leg was ripped from her body. As the invalids quickly become enraged aggressors, Cherry and her ex-boyfriend El Wray lead a team of accidental warriors into the night.