One month after the events of the first season, Citadel spies are underground and being hunted by Manticore agents around the world. They're pulled out of hiding to join forces with a new team of unconventional spies when Manticore's Brazilian billionaire Paulo Braga threatens to unleash a cataclysmic piece of technology, built by Citadel's own Bernard Orlick, into the world.

故事设定在闷热难耐的亚特兰大。主人公安娜（泰莎·汤普森 饰）如幽灵般深居简出，逐渐淡出朋友圈和新闻主播的职业轨道。然而当偶然听闻达洛尼加——那个养育她的沉寂小镇——发生谋杀案时，她沉寂的生命骤然重燃，立即投身案件追寻真相。杰克·哈珀警探（乔·博恩瑟 饰）却对她的介入异常怀疑，将她列为自身调查的焦点。同一个故事总有他的版本与她的版本——这意味着总有人在说谎。