Martine is 25. Since breaking up with François, she has the feeling that the world is caving in on her. Between small jobs and one-night stands, she can't seem to get a fix on herself. In desperation, after a last quarrel with François, she unintentionally causes an accident that leads her to the emergency ward of a psychiatric hospital. During her brief stay, she unexpectedly sparks into life. She takes an interest in two young patients, Pierre and Anne, convinced that she is doing the right thing in supervising their love life...

Antoine is a failed and depressed writer. Fred doesn't do much in his life and seems to be happy about it. The two of them share an apartment and live in a shambles. The adventures and mostly the misadventures of these two buddies/losers, makes them realise that despite everything that happens their friendship is the most important thing in their lives.