Sarah Jordan, an American living in London in 1984, is married to the son of a wealthy British industrialist. She encounters Nick Callahan, a renegade doctor, whose impassioned plea for help to support his relief efforts in war-torn Africa moves her deeply. As a result, Sarah embarks upon a journey of discovery that leads to danger, heartbreak and romance in the far corners of the world.

In 2019, Lincoln Six-Echo is a resident of a seemingly "Utopian" but contained facility. Like all of the inhabitants of this carefully-controlled environment, Lincoln hopes to be chosen to go to The Island — reportedly the last uncontaminated location on the planet. But Lincoln soon discovers that everything about his existence is a lie.