It's a hot summer day in June, 1969. Marsha throws herself a birthday party and dreams of performing at a club in town, but no one shows up. Sylvia, Marsha’s best friend, distraught from an unsuccessful introduction between her lover and her family, gets so stoned she forgets about the party. Marsha, Sylvia, and friends eventually meet at the Stonewall Inn to celebrate Marsha's birth. When the police arrive to raid the bar, Marsha and Sylvia are among the first to fight back.

The history of New York’s Meatpacking District, told from the perspective of transgender sex workers who lived and worked there. Filmmaker Kristen Lovell, who walked “The Stroll” for a decade, reunites her community to recount the violence, policing, homelessness, and gentrification they overcame to build a movement for transgender rights.
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Describing herself as a 'street queen,' Johnson was a legendary fixture in New York City’s gay ghetto and a tireless voice for LGBT pride since the days of Stonewall, who along with fellow trans icon Sylvia Rivera, founded Street Transvestites Action Revolutionaries (S.T.A.R.), a trans activist group based in the heart of NYC’s Greenwich Village. Her death in 1992 was declared a suicide by the NYPD, but friends never accepted that version of events. Structured as a whodunit, with activist Victoria Cruz cast as detective and audience surrogate, The Death and Life of Marsha P. Johnson celebrates the lasting political legacy of Johnson, while seeking to finally solve the mystery of her unexplained death.