On its way back to Earth, the space shuttle Nautilus passes through a cloud of alien spores causing its sole occupant, astronaut Steve Thomas to transform into a blood-thirsty monster. The shuttle crashes into a swampy region of central Florida, creating a situation which threatens contagion and/or death to all who encounter the shuttle or its mutated pilot.

In a backward post-apocalyptic world, She aids two brothers' quest to rescue their kidnapped sister. Along the way, they battle orgiastic werewolves, a psychic communist, a tutu-wearing giant, a mad scientist, and gladiators before standing against the odds to defeat the evil Norks.