Young filmmakers trying to hawk a movie titled "Bradykillers" about a serial killer who goes after victims Marcia, Jan, and Cindy meet their screen idol, William Shatner. The two young men, who idolize him and in their fantasies have seen him as a shadowy fairy godfather figure, are alarmed at the reality of the middle-aged non-Captain Kirk man that they meet.

At Guesta Verde University, deranged Professor Curien is trying to revive the dead, killing students for the experiment. As such, there's an outbreak of zombies, and the government sends a NSA medical research team, formed by Dr. Alexandra 'Nightingale' Morgan and Lt. Ellis, with a special force leaded by Lt. Dalton, trying to get the zero sample from the first generation zombie. The team has little time to accomplish and depart before missiles are sent to destroy the area.

On an island off the coast, a techno rave party attracts a diverse group of college coeds and a Coast Guard officer. Soon, they discover that their X-laced escapades are to be interrupted by zombies and monsters that attack them on the ground, from the air, and in the sea, ruled by an evil entity.

Michael returns to Haddonfield for Jamie Lloyd – the orphaned daughter of Laurie Strode – and her babysitter Rachel. Can Dr. Loomis stop him before the unholy slaughter reaches his innocent young niece?

One year later, Michael Myers' traumatized young niece is horrified to discover she has a telepathic bond with her evil uncle... and that he is on the way back to Haddonfield to begin the carnage again.