Dagwood Bumstead poses as his boss Mr. Dithers so that a big business deal can be consummated while Dithers avoids nearsighted process server Jim Gray. The upshot of all this is that Dagwood ends up in a lunatic asylum, forcing Blondie to come to the rescue.

Baby Dumpling, the six-year-old son of Blondie and Dagwood Bumstead disappears from sight during his first day at school. While Dagwood frantically combs the city in search of the boy, Baby Dumpling spents a nice, safe afternoon with poor little rich girl Melinda Mason, who with her new playmate's help arises from her sickbed to walk across the room for the first time in months.

Dagwood brings home a pedigreed Great Dane which an important company client wants and which Blondie enters in the big dog show.

The Bumstead family is off to see relatives in the country when Blondie runs into Charlie and Millie, an eloping couple needing her help.

Dagwood wants to join the trout club and Blondie wants a fur coat. Jealousy reigns when Dag's old girlfriend Joan shows up, but nothing else matters when a drawing at the movie theatre provides money for the coat.

Mr. Dithers invites the Bumsteads on a South American cruise. Somehow Dagwood winds up as the female drummer in the ship's band, while Penny Singleton gets to show off her Broadway background in some lively musical numbers.

Blondie and Dagwood are about to celebrate their fifth wedding anniversary but this happy occasion is marred when the bumbling Dagwood gets himself involved in a scheme that is promising financial ruin for the Bumstead family.