When an explosion at a top-secret government lab injures an elderly janitor, no one could have expected the terrifying results. Exposure to mysterious chemicals causes him to undergo a bizarre transformation. He is slowly... incredibly... growing younger every day. Now, a ruthless CIA assassin will stop at nothing to take him prisoner and turn him into a government guinea pig. With his future on the line, the janitor goes on the run with his wife and a feisty female agent. All the while, he continues to transform... into a being with powers that are as deadly as they are unimaginable.

The teenager Madison McBride is traumatized by the loss of her deranged father when she was nine years old and the suicide of her beloved brother Brandon one year ago. She decides to join the Richard Miller University, where Brandon committed suicide, to overcome her demons. While walking to her dorm, she meets the weird janitor Wilbur Mackey that tells her that the place is haunted.

When a tabloid reporter and his son travel to a quiet Midwestern town to investigate a gruesome massacre, they fall victim to a possessed orphan named Micah.