故事围绕着一枚名叫“亚历山大之泪”的名贵戒指展开。神村零（松坂桃李 饰）身为女性却有着矫健的身手，作为一名神偷，只要她想，没有什么是到不了手的。和体能派的神村零不同，岸原大雅（福士诚治 饰）走得是真真正正的“技术流”。除去这两人之外，还有同行片桐夏莲（大政绚 饰），这三名怪盗，围绕着戒指展开了一场你死我活的争斗。
奇怪的是，三人所接受的竟然同一人的委托，此人意欲何为成为了无法解开的谜团。随着时间的推移，刚开始的争斗渐渐变味，三名怪盗开始对藏在这枚戒指背后的故事和历史产生了兴趣，一股凶恶势力的出现更是让三人站到了统一的战线之上。

Researchers unearth a long-lost page of "The Travels of Marco Polo" and discover it's a clue to a lost treasure! Lupin appears to swipe the tablet, but he leaves empty-handed... and as a murder suspect! He shrugs off being framed for the death of an archaeology professor just enough to go treasure-hunting. Tailed by both a weapons dealer and ICPO Inspector Zenigata, Lupin must rely on his gunslinging partner Jigen and the professor's granddaughter Lisa to stay two steps ahead. Meanwhile, the swordsman Goemon rethinks his devotion to the blade and finds romance deep in the mountains. Two tales collide in a worldwide adventure packed with history and laughs!