College students exploring an abandoned insane asylum accidentally shatter canisters holding the cremains of former mental patients. Inhaling the dusty ash filling the air, they're soon possessed by the souls once held within them. One is a convicted serial killer from 1950.

Set in 1964, a three-day journey along Route 66 begins when Bobby Falls, a 19-year-old serial killer, hitches a ride with Jim Goodwin, a celebrity animal handler travelling with his precious cargo: his TV chimpanzee, Spanky.