A pair of Siamese twins are separated and one is forced to live a sheltered existence under the watchful eye of a controlling psychiatrist.

Bernie works at a Las Vegas casino, where he uses his innate ability to bring about misfortune in those around him to jinx gamblers into losing. His imposing boss, Shelly Kaplow, is happy with the arrangement. But Bernie finds unexpected happiness when he begins dating attractive waitress Natalie Belisario.