Sarah, a struggling young woman, agrees to volunteer as a test subject and be implanted with the LEXX nanochip for a pharmaceutical company experiment. She hopes that the money received for her participation will solve her financial troubles. When the implant turns sinister and orders her to commit crimes, Sarah is plunged into a murderous spiral with only one choice: to live or die.

Shifting from one pocket to another, from one man's drama to another, a lowly dollar bill, 'one buck' takes us on an odyssey through the heart of a forgotten town in Louisiana.