Mi Vida Loca tells the story of young Mexican-American women in Los Angeles and the struggles they have in a life of gangs, drugs, and personal betrayal. Mousie (Seidy López) and Sad Girl (Angel Aviles) are best friends from childhood, growing up in gang-infested Echo Park and remaining loyal to each other. But when Sad Girl sleeps with Mousie's boyfriend (a drug dealer who is killed) and becomes pregnant, their friendship is ruptured. As the violence of their neighborhood erupts around them, they must try to stay together as friends despite their betrayals. This is an unforgiving look at a world where women seem to have no choice but to raise their children, deal drugs, and survive by whatever means necessary.

A group of actors and their casting agents try to find a direction in their lives whilst coming to terms with their personal problems and relationship conflicts.