Georges (Grégory Gadebois), teaches school in Montreal – he and wife Emma, (Monia Chokri) have just moved to the countryside. One day, he surprises a young intruder Zack, (Noah Parker), rummaging through his things.

Estelle, 34, wife and mother of the family without history, sinks into a tidy, predictable life. But a series of events puts her identity in question. Worse, she realizes that the crux of the crisis is sexual. She decides to organize a "threesome". Challenge away from his comfort zone. She plunges into this mad quest, resulting with her spouse who feels just as incompetent.

Twelve-year-old Simone feels painfully disconnected from the world after witnessing the brutal death of her mother. Simone, a solitary multimedia artist in her twenties, is struggling to control her crushing panic attacks and keep her day job in an underground parking lot. And Simone, a sixty-year-old physicist, is giving a conference on the nature of time. The three Simones' lives are intertwined in a labyrinthine meta-world where timeframes overlap, characters multiply, and storylines repeat and expand. But, for all its shuttling forward and back through time, ENDORPHINE remains grounded in the Simones' inner lives — it's an artistic examination of scientific phenomena that also poignantly explores how people deal with trauma.

The Gamache, tailors from father to son, have been dressing the Mafia family Paternò for three generation. Vincent "Vince" Gamache works on behalf of Frank the godfather with his eldest son Giaco. Vince, reckless and rash, seeks to earn his stripes by impressing the godfather. Without the Paternò knowing, he stages a big operation and is promoted. Fuming with jealousy, Giaco discovers that Vince committed a monstrous act during his stroke. The Gamache disown Vince and war begins.