When Detective Mortimer Shade is somehow killed in a freezer, a parasite called a grail possesses his body, revives him, but he needs blood to stay alive. His partner John Dark accepts the new situation and together they become vigilantes, judging and killing the bad guys, with Shade sucking their blood with his claw. However, Dark notes that Shade is losing the rest of his humanity and becoming a monster, being aware and afraid of the danger Shade represents to mankind and trying to stop him.

A group of young bio-engineers discover they can use quantum physics to transfer motor-skills between human brains. Believing this to be a first step towards a new intellectual freedom, they freely distribute the technology. But as the mysterious past of one of their group is revealed, dark forces emerge that threaten to subvert this technology into a means of mass control. DxM takes the mind-bender thriller to the next level with an immersive narrative and breath-taking action.

主人公考兹是一个很神秘的枪手。因为身为修女的母亲，当初背叛了对上帝的誓言私自生下他，使得考兹一直背负着诅咒：每一个死于他枪下的人都会重新复活。不久，被考兹杀死的一伙人，以恶人坎撒为首，都复活过来找他寻仇。为了应付这种局面，考兹也给自己找了一个名叫范布鲁斯的年轻勇士一起并肩战斗……