The Warner Brothers (and the Warner Sister) go on a quest to find a fallen wishing star to help Dot with her illness. Unfortunately the rest of the town, including an evil king, also hear about the star and want to get to it first to have their own wishes come true. It's a race against time and it's up to the three zany siblings to get there first.

本片讲述了随着钻石的神秘失踪，伦敦警方组织了很多侦探去查找罪犯，汤姆和杰瑞就是一对组合。棘手的案件让这对猫鼠痛苦不堪，只能寻求世界上最棒的侦探的帮助，他就是夏洛克·福尔摩斯先生。

Ensemble cast of off-the-wall Warner Brothers characters, appearing in a wide variety of roles. Wakko, Yakko, and Dot Warner, are WB Studio creations who were just too "zany" to be of any use to the studio. Pinky and the Brain are two mice bent on world domination. Rita and Runt are a cat and dog team, who get into perilous situations every episode, put always seem to find time to sing a song. Bobby, Pesto, and Squit are the Goodfeathers, part of a New York mob of pigeons, who worship Martin Scorsese. Slappy the Squirrel is a late middle-age squirrel; she starred in a series of popular cartoons in the Golden Age. Buttons is a watch-dog, charged with watching the mischievous toddler, Mindy. Chicken Boo is a giant chicken trying to integrate into human society. Flavio and Marita are two urbane hippopotami.