Jung-Woo (Kim Sung-Su) is a neurosurgeon and also works in bioengineering research. He is married, but has an ongoing relationship with Yoo-Gyeong (Han Go-Eun). She is a doctor and stands by Jung-Woo. Yoo-Gyeong has a mysterious accident one day and her hand is cut off in the accident. Thanks to Jung-Woo's quick thinking, her hand is reattached successfully with surgery. Yoo-Gyeong's health improves after the surgery, but bizarre events take place around her constantly.
Do-chul is a boxer who never wins a game. While trying to make some money, he gets involved with Hong-ki, a small-time crook. They somehow make friends and hang around together, but their views toward life and the world are almost opposite.