Mean and domineering Jane and the sweet and ditsy Jackie are two radically contrasting sisters who suffer from severe trauma after witnessing the murder/suicide of their parents as well as seeing their other sibling Janice raped and killed by her assailants. The pair are deemed fit to re-enter society and get released from a sanitarium where they have undergone extensive rehabilitation therapy. However, Jane and Jackie prove to be anything but sane and harmless as they embark on a vicious spree in which they torture, murder, and mutilate any man luckless enough to cross their lethal paths.

Dr. Victor Frankenstein neglects the sexual needs of his frigid and frustrated wife Helena. After Helena gets killed in a horse riding accident, Victor decides to bring her back to life. However, Victor's inept assistant Igor accidentally damages Helena's brain and replaces it with a lesbian's brain, so Helena is now a crazed, aggressive, and predatory vixen with a raging insatiable libido.

Jane and Jackie are driven far beyond the brink of madness after witnessing the brutal rape and murder of their younger sister by a group of marauding college fraternity brothers. Upon the release from an insane asylum, the sisters embark on a relentless search for the guys that raped and strangled their sister. Obsessed with revenge and fueled by a hatred of all men, they kill any man that crosses their path, retaining his severed genitals as a trophy.