Caitlin Fairchild, is a teenager who is offered a place in an institute for gifted children. She soon learns that the school isn't really a school, but rather a military project to turn children with a special genetic structure into super soldiers. After developing incredibly enhanced abilities, Caitlin rebels against the program that created her. But all is not what it appears; there are some in the military who want to help her, and a deadly enemy is actually a long lost sibling.

The world is under attack by an alien armada led by the powerful Apokoliptian, Darkseid. A group of superheroes consisting of Superman, Batman, Wonder Woman, The Flash, Green Lantern, Cyborg, and Shazam must set aside their differences and gather together to defend Earth.

A mysterious new villain known only as Hush uses a gallery of villains to destroy Batman's crime-fighting career as well as Bruce Wayne's personal life, which has been further complicated by a relationship with Selina Kyle/Catwoman.