In the hazy aftermath of an unimaginable loss, Sarah and Phil come unhinged, recklessly ignoring the repercussions. Phil starts to lose sight of his morals as Sarah puts herself in increasingly dangerous situations, falling deeper into her own fever dream.

Fulfilling a promise to his deceased father, one-time outlaw Jesse Custer returns home to West Texas to take over his dad's church. Jesse's mission, however, becomes twisted when his body is overcome by a cryptic force that unleashes within him a highly unconventional power. Together with hell-raising ex-girlfriend Tulip and Irish vagabond Cassidy, the preacher-in-training embarks on a journey to find God in a world inhabited by holy, hellish, and everything-in-between characters.