When Santo accompanies a troupe of archaeologists in the search for Aztec artifacts, they find the Mummy of an Aztec who leaves a warning to those who tamper with his resting place. The adventurers ignore the warning, and before long, the Mummy starts bumping them off one-by-one with his bow & arrow.

After facing defeat at the hands of Cristaldi the magician, Dracula is back to seek revenge and rule the world. With the help of Wolfman and his legion of followers, victory seems eminent. Professor Cristaldi, a descendant of the magician, is warned about Dracula's plans and calls upon El Santo and Blue Demon in the hopes that they can put the infamous Count and the werewolf down for good.