Two girls run away from a mental institution and forge a relationship on the streets of New York. They soon begin enjoying their punk-rock life until the powers that be start nosing around, looking for them, unsettling their already delicate mental states. Will the Sleez Girls be torn apart? Or will they tear themselves apart?

After murdering a young would-be actress, megalomaniacal movie director Chris Neville sets about making a feature based on the murder, casting the dead woman's clueless husband as the patsy, and finding a dead ringer to play the part of the dead actress.