Wes Merritt and his daughter Natalie (14) get more than they bargained for when they buy an old house that was formerly inhabited by the nice old Mrs. Ashboro and her pet cat, Margaret. When strange things start happening in the house, all fingers point to the presence of Margaret, who died the same day as Mrs. Ashboro. But why has she come back to haunt them?

As they enter their third year of medical school, a group of young students must prepare to decide what they intend to specialize in. Somehow, they must impress the Chief of Surgery while learning how to survive the life-and-death area of medicine and the complexity of their everyday lives.

When smart, musically talented and popular high school student David Sinclair unexpectedly commits suicide, shock and unanswered questions reverberate throughout the school. David was perfect, so where did he or his friends go wrong? His best friend, Chris Townsend (Reeves), struggles with his friend's death and asks himself if he too is capable of self-destruction.