The Panther women are worshipers of Satan and perform rituals in their honor and sacrifice. The fighters will face them up and down the ring.

In Sierra Negra, graverobbers Barraza and Mendoza steal the coffin of Count Karol de Lavud, before heading to a hospital. Barraza sees a medallion upon the coffin's opening and demands more money from Mendoza. Meanwhile, Marta González, recovering from traumatic events, works as a nurse with Dr. Saldívar. When Barraza removes the wooden stake in order to steal Lavud's medallion, the vampire returns to life and begins a crime spree, hunting down Marta to marry her.

In 1661 Mexico, the Baron Vitelius of Astara is sentenced to be burned alive by the Holy Inquisition of Mexico for witchcraft, necromancy, and other crimes. As he dies, the Baron swears vengeance against the descendants of the Inquisitors. 300 years later, a comet that was passing overhead on the night of the Baron's execution returns to earth, bringing with it the Baron in the form of a horrible, brain-eating monster that terrorizes the Inquisitor's descendants

A pretty young Mexican girl returns to her hometown to make funeral arrangements for her beloved aunt, who has just died. Soon she begins to hear disturbing stories about the town being infested by vampires, and she eventually begins to suspect that her remaining aunt and the mysterious next=door neighbor may be involved.