Unlucky in love, chemist Paul Matthews visits gypsy Madame Rosa for help. Quickly realizing he is a hopeless nerd, she gifts him with Love Potion No. 8, which makes anyone who wears it irresistible to the opposite sex for four hours. Paul and animal psychologist coworker Diane Farrow decide to test it on themselves. The awkward pair suddenly find themselves alluring to anyone they approach, but soon realize they are most attracted to each other.

Two carefree pals traveling through Alabama are mistakenly arrested, and charged with murder. Fortunately, one of them has a cousin who's a lawyer - Vincent Gambini, a former auto mechanic from Brooklyn who just passed his bar exam after his sixth try. When he arrives with his leather-clad girlfriend, to try his first case, it's a real shock - for him and the Deep South!