Kickboxing champion Matt Reeves witnesses the murder of his friend Johnny. While investigating the crime, he learns that a Mr. Negaal in South Africa has founded a new kickboxing association and does not leave international champions much of a chance. Johnny had to pay with his life when he did not want to join. Neegal seems to kill everybody who is in his way especially David Sloan from the previous Kickboxer films. Matt is on his own now, but suddenly finds an unexpected ally.

Vusi Madlazi returns to the South African village he left as a young boy to bury his father. He meets up with his brother Ernest, who tells him their other brother Stephen couldn't be contacted. Vusi goes to Johannesburg to find him, but at first can only find his neighbor/girlfriend, Karin, a stripper. Vusi proceeds to learn how conditions have changed since the end of apartheid, not always for the better for black men.