Gun salesman Steve Farrell gets two of his new Colt .45 pistols stolen from him by ruthless killer Jason Brett but vows to recover them.

Wildcatter Jeff Dawson does his best to bring in a gusher in Mexico despite continual bandit raids. He asks for help from his ex-employer Ward Conway, but Conway, now married to Dawson's ex-lover Marina refuses, fearing that his wife will want to renew her romance with the other man.

Following the surrender of Geronimo, Massai, the last Apache warrior is captured and scheduled for transportation to a Florida reservation. On the way he manages to escape and heads for his homeland to win back his girl and settle down to grow crops. His pursuers have other ideas though.

An Australian sheep man comes to Montana looking for grazing space, is opposed by local ranchers and a wealthy cattle-woman.

White settlers plan to defy the agreement between the government and the Comanche to mine for silver on Comanche lands, while scout Jim Bowie tries to keep the peace in the territory.

Jefty, owner of a roadhouse in a backwoods town, hires sultry, tough-talking torch singer Lily Stevens against the advice of his manager Pete Morgan. Jefty is smitten with Lily, who in turn exerts her charms on the more resistant Pete. When Pete finally falls for her and she turns down Jefty's marriage proposal, they must face Jefty's murderous jealousy and his twisted plots to "punish" the two.

A boy haunted by nightmares about the night his entire family was murdered is brought up by a neighboring family in the 1880s. He falls for his lovely adoptive sister but his nasty adoptive brother and mysterious uncle want him dead.

On the outskirts of town, the hard-nosed Vienna owns a saloon frequented by the undesirables of the region, including Dancin' Kid and his gang. Another patron of Vienna's establishment is Johnny Guitar, a former gunslinger and her lover. When a heist is pulled in town that results in a man's death, Emma Small, Vienna's rival, rallies the townsfolk to take revenge on Vienna's saloon – even without proof of her wrongdoing.