When the night falls, and the creatures of the dark are crawling out of the shadows, there is only one man who stands between us and evil: Edward Carnby.

At Guesta Verde University, deranged Professor Curien is trying to revive the dead, killing students for the experiment. As such, there's an outbreak of zombies, and the government sends a NSA medical research team, formed by Dr. Alexandra 'Nightingale' Morgan and Lt. Ellis, with a special force leaded by Lt. Dalton, trying to get the zero sample from the first generation zombie. The team has little time to accomplish and depart before missiles are sent to destroy the area.

Edward Carnby is a private investigator specializing in unexplainable supernatural phenomena. His cases delve into the dark corners of the world, searching for truth in the occult remnants of ancient civilizations. Now, the greatest mystery of his past is about to become the most dangerous case he has ever faced.

Jack Carver, a former member of the Special Forces takes the journalist Valerie Cardinal to an Island to visit her uncle Max who is working in a Military complex on the Island. As they arrive Valerie gets captured by the minions of Doctor Krüger. After the destruction of his boat Jack finds out about the true purpose of the Facilities on the Island, which is the creation of genetic soldiers.