Recently promoted and transferred to the homicide division, Inspector Jessica Shepard feels pressure to prove herself -- and what better way than by solving San Francisco's latest murder? However, as Shepard and her partner, Mike Delmarco, soon discover, the victim shared a romantic connection to her. As more of Shepard's ex-lovers turn up dead, her mind starts to become unstable, and she begins to wonder if she could be the very killer she's trying to track down.

Milo Boyd, a down-on-his-luck bounty hunter, thinks he's seeing an upswing in fortune when he gets a call to bring in his bail-jumping ex-wife, a reporter named Nicole. Milo considers the job an easy payday, but Nicole quickly escapes to chase a lead on a murder case. The former spouses play an escalating game of one-upmanship, until they suddenly find themselves on the run for their lives.