25 year old Danny Hill's grandmother just died giving Danny the chance to move into her enormous rent controlled apartment in Manhattan. Danny must lock himself in for twelve days before he can take over the lease. There's just one problem -- he may not be the only occupant.

A biological experiment goes bad, this time releasing a gaggle of mutated great white sharks with a taste for human flesh. Soon enough, shark expert Nick West is on the case, leading a crew to study them and eventually bring them back into captivity. West's plans hit a snag, however, when Australian shark hunter Roy Bishop is called in to wipe out the fishy menace.

When plans for a weekend vacation hit a dead end, a group of close-knit friends find themselves stranded in unfamiliar territory, pursued by a menacing, blood thirsty predator. Holed up in an isolated cabin, tensions mount as long-buried secrets are revealed. As the body count rises, the group must put their differences aside and fight for survival.