4400 overlooked, undervalued, or otherwise marginalized people who vanished without a trace over the last hundred years are all returned in an instant, having not aged a day and with no memory of what happened to them. As the government races to analyze the potential threat and contain the story, the 4400 themselves must grapple with the fact that they've been returned with a few "upgrades", and the increasing likelihood that they were all brought back now for a specific reason.

After an act of bullying sends Javier to the hospital, he begins experiencing visions that foresee glimpses of shocking murders at his school right before they happen. Now, in between navigating the social hierarchies and prejudices of clique culture, Javier and his best friend Bianca must try to unmask a serial killer before he strikes again.

Jonny Baptiste is a reckless teen sent to live with her estranged Aunt Hildie. On the event of her eighteenth birthday, she experiences a radical metamorphosis: a family spell that redefines her called Forevering. When several teen girls go missing at her new school, a mythically feral Jonny goes after the Perpetrator.