On the eve of Senior Year, Scott and his friends find themselves facing the possibility of a future without each other, a next phase of their lives that might take them in different directions despite their best intentions. Little do they know that outside forces are already plotting to break the pack apart long before they ever see graduation; new villains that use a combination of science and the supernatural for a malevolent and mysterious purpose that will eventually pit Scott and his friends against their greatest enemy yet.

《犯罪心理》第十三季讲述美国联邦调查局总部下属的行为分析科部门（BAU）中，行为分析师们剖析最棘手的案件，分析凶手的心理和作案特征，并在他们再次施暴前预测出他们的下一步行动，协助当地警察捉拿凶手。