America's three top leisure-time activities come roaring to life in National Lampoon's Favorite Deadly Sins. This film consists of three short stories: Greed (Joe Mantegna), Anger (Andrew Clay) and Lust (Denis Leary).

Student nurses join some doctors to work in a medical station a few hours flying-time from the Mexican town of Catamaco. One of their planes goes down due to an engine malfunction and crashes in the rain forest. This is the story of the attempts to save the lives of the passengers (both nurses and doctors).