Ensemble cast of off-the-wall Warner Brothers characters, appearing in a wide variety of roles. Wakko, Yakko, and Dot Warner, are WB Studio creations who were just too "zany" to be of any use to the studio. Pinky and the Brain are two mice bent on world domination. Rita and Runt are a cat and dog team, who get into perilous situations every episode, put always seem to find time to sing a song. Bobby, Pesto, and Squit are the Goodfeathers, part of a New York mob of pigeons, who worship Martin Scorsese. Slappy the Squirrel is a late middle-age squirrel; she starred in a series of popular cartoons in the Golden Age. Buttons is a watch-dog, charged with watching the mischievous toddler, Mindy. Chicken Boo is a giant chicken trying to integrate into human society. Flavio and Marita are two urbane hippopotami.