Birdwatchers, activists, scientists, and a film crew unknowingly converge in Bigfoot's neck of the woods, where something even more sinister lurks.

Every neighborhood has a Karen, and Amityville is no exception. When stealing a cursed bottle of wine from a struggling local brewery, Karen soon finds that the price to pay is far more dangerous than your average hangover. Everyone in her path becomes prey, and not even a manager can be called in to stop her.

An engaged Muslim doctor, her fiancé, and their friends go on a holiday at St. Joseph’s Guesthouse, unaware that it was the site of a sacrifice of an innocent centuries before. They soon come to believe that it's haunted and causing them to go crazy, as their emotions spiral out of control.