Hopalong Cassidy, boss of the Bar 20 ranch in Texas, rides down the Camino Real in the New Mexico cattle country near Alamogordo, in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he and his saddlemates, "Lucky" Jenkins and "Pappy", can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out. Seeing Cassidy as a menace to his plans, he has him arrested on a trumped-up charge. Cassidy and his pals shoot their way out of the trouble and reach Nora;s ranch where they learn that Allison's henchmen have murdered her foreman, Tom Dillon, and Allison has sent for a crew of outlaws on the Texas border.

The owner of a border town gambling saloon falls in love with a promiscuous young girl. When she has an affair with another, he tosses her out of town. She gets revenge by marrying his younger brother.

Heading west for his health, Colonel Lambeth takes his daughter Rill along. Lost on the desert they are saved by Pecos and Chito. The Colonel hires the two and the Lambeths soon find themselves mixed up in Pecos' trouble. Pecos has killed Sawtelle's brother and Sawtelle as head of the vigilantes is after him.

It's 1860 and the old Spanish land grants are being surveyed. Montez is after part of Don Regas' rancho and gets the surveyor to alter the boundary. But Don Regas still has the original grant written on a bandanna. Montez sends Indians after it but Bill Cody and Gabby fight them off and a wounded Gabby unknowingly ends up with the missing million dollar deed wrapped around his arm for a bandage.