A young woman who learns that one of her ancestors had been burned at the stake as a witch decides to exact her revenge on the descendants of the people who had her killed.

Doc Holliday travels to Tombstone, Ariz., with prostitute Katie Elder. Although the trip is difficult because Doc is ill with tuberculosis, they eventually reach their destination, where Holliday is reunited with his old friend Marshal Wyatt Earp, who has been clashing with the Clanton gang. Tensions between Earp and the Clantons rise until their infamous final showdown brings it to a head.