The story of how a mysterious suitcase brings together, and changes, the lives of a divorced dad, an unhappy housewife, two hitmen, a pair of street thugs, two love struck teens, two FBI men and a psychedelic toad. Based on Pulitzer Prize-winning humorist Dave Barry's best-selling first novel, "Big Trouble."

Novelist Hank Moody struggles to help raise his 13-year-old daughter, while carrying a torch for his ex-girlfriend Karen. His obsession with honesty and his self-destructive behavior are simultaneously destroying and enriching his career. . . all this in the city he loathes the most: Los Angeles.

Joey Boca is the owner of a pizza parlour, and has been married to Rosalie for years. When Rosalie discovers that Joey is a womanizer and has been cheating on her for a long time, she goes to extreme lengths to punish him.