Before their eventual team-up with Scooby and the gang, bright and optimistic Daphne and whip-smart and analytical Velma are both mystery-solving teens who are best friends but have only met online - until now. Daphne has just transferred to Velma's school, Ridge Valley High, an incredible tech-savvy institute with all the latest gadgets provided by the school's benefactor, tech billionaire Tobias Bloom. And while competition is fierce among the students for a coveted internship at Bloom Innovative, Daphne and Velma dig beyond all the gadgets and tech to investigate what is causing some of the brightest students in school to disappear - only to emerge again in a zombie-fied state.

After a talent scout spots her performing with her dog Boi at a charity gala, Sharpay Evans sets off for the bright lights of NYC, convinced instant fame and fortune are in the bag. But theatre's a dog-eat-dog world. Fortunately, Sharpay also meets Peyton, a handsome student filmmaker who finds Sharpay nearly as fascinating as she finds herself.