A hardened criminal fresh out of the joint takes a job as a handyman in a dilapidated house; but the twisted horrors he finds inside are enough to send anyone running. So why does he stay? And why are so many people drawn to Penance Lane?

Deuce Bigalow goes to Amsterdam after a little accident including two irritating kids and a bunch of aggressive dolphins. There he meets up with his old friend T.J. Hicks. But a mysterious killer starts killing some of Amsterdam's finest gigolos and T.J. is mistaken for the extremely gay murderer. Deuce must enter the gigolo industry again to find the real murderer and clear T.J.'s name.