Come Back, Africa chronicles the life of Zachariah, a black South African living under the rule of the harsh apartheid government in 1959.

The film chronicles three desperate days in a then impoverished lower Manhattan neighborhood, New York's skid row: the Bowery. It is the story of Ray (Ray Salyer), a railroad worker, who drifts on to the Bowery to have a drunken spree after a long bout of laying tracks and then falls in with a band of drunks who help him spend his money.
Ray, the "new guy on the Bowery," whose biceps still fill out his sleeves, looks preoccupied as he enters the "Confidence Bar & Grill". Surrounded by various alcoholics in advanced states of decay, he buys them rounds of drinks, then blacks out on his first night, and wakes up to discover that his suitcase has been stolen.
The thief (Gorman Hendricks) becomes the closest thing he has to a friend...and just like that, Ray embarks on a trip to hell, becoming part of the Bowery. In a series of Beckettian portraits, the protagonists, congregations of winos, listless listeners, blubber through numerous bar scenes, games of dominos around a flophouse stove, and a sermon at the Bowery Mission. Will Ray find his way out of this uncaring urban jungle?