An American writer in England takes his children and a newly hired nanny on a trip to South Africa while his wife, a reporter, is on assignment. He has an affair with the nanny, but when he refuses to leave his wife for her, the nanny gets her revenge by kidnapping his children.

In the quiet waters of the Mississippi, body parts are being discovered. No one knows what is behind it all, until a huge man eating bull shark turns up. This bull shark is different, as it can breath in fresh water, making a deadly encounter between anyone who comes before it. John Sanders must now try and reach the surface, with his ex-wife and whilst being held hostage.

The lethal Reaper virus spreads throughout Britain—infecting millions and killing hundreds of thousands. Authorities brutally and successfully quarantine the country but, three decades later, the virus resurfaces in a major city. An elite group of specialists is urgently dispatched into the still-quarantined country to retrieve a cure by any means necessary. Shut off from the rest of the world, the unit must battle through a landscape that has become a waking nightmare.