科尔（布鲁斯·格林伍德 Bruce Greenwood 饰）是一位野生动物专家，目前，他正在负责制作和解说一档有关于亚马逊热带丛林的纪录片。然而，就在此过程中，他竟然神秘失踪，从此了无音信，留下妻儿孤苦伶仃度日。
对于丈夫的失踪，苔丝（莱斯利·霍普 Leslie Hope 饰）百思不得其解，科尔的儿子林肯（乔·安德森 Joe Anderson 饰）更是急切地想要寻找父亲的踪迹，就这样，两人决定踏上前往亚马逊丛林的旅途。他们集结了一支实力强劲的队伍，包括了科尔曾经的朋友和同事们，更有经验丰富的克拉克（保罗·布莱克索恩 Paul Blackthorne 饰）解囊支持，他要将寻人的整个过程拍摄下来，作为制作纪录片的素材。

The Practice focused on the law firm of Robert Donnell and Associates (later becoming Donnell, Young, Dole, & Frutt, and ultimately Young, Frutt, & Berluti). Plots typically featured the firm's involvement in various high-profile criminal and civil cases that often mirrored current events at the time of the episodes' initial broadcast. Conflict between legal ethics and personal morality was a recurring theme.

Just as Daniel and Kristi welcome a newborn baby into their home, a demonic presence begins terrorizing them, tearing apart their perfect world and turning it into an inescapable nightmare.

A mentally unhinged factory worker must decide whether to listen to his talking cat and become a killer, or follow his dog's advice to keep striving for normalcy.