Follows Caligula as he kills his devious adoptive grandfather and takes control of the decadent Roman Empire, spiralling into depravity, devastation, and madness.

After winning a game show contest, a newlywed couple travels to New Orleans where the husband seeks to reclaim his ancestral plantation mansion from his biracial stepbrother.

Myron Breckinridge is waiting for his sex-change operation while a stoned surgeon stumbles into the operating room. Before the drugged doctor begins Myron's operation, he counsels him. Myron persists and the doctor goes through with it. An enthusiastic audience observing the operation applauds the medical achievement and rises in a standing ovation. After the operation, Myron arrives in Hollywood as Myra while in the rest of the film Myron pops up from time to time as Myra's alter ego. Myra goes to an acting academy owned by her uncle, Buck Loner, a former cowboy star. The real reason for Myra's arrival is to claim her half of Uncle Buck's estate, which she says she's entitled to. Buck Loner stalls by giving her a job teaching the history of motion pictures. Buck Loner has several friends. One of them is Letitia Van Allen, an ancient Hollywood talent scout. The sex-starved septuagenarian runs an acting agency "for leading men only."

When a crooked sheriff murders his employer, William "Billy the Kid" Bonney decides to avenge the death by killing the man responsible, throwing the lives of everyone around him into turmoil, and endangering the General Amnesty set up by Governor Wallace to bring peace to the New Mexico Territory.

Near the end of World War II, General Dietrich von Choltitz receives orders to burn down Paris if it becomes clear the Allies are going to invade, or if he's unable to maintain control of the city. After much contemplation, Choltitz ignores orders, enraging the Germans and giving hope to various resistance factions that the city will be liberated. Choltitz, alongside Swedish diplomat Raoul Nordling, helps a leader organise his forces.

The only son of wealthy widow Violet Venable dies while on vacation with his cousin Catherine. What the girl saw was so horrible that she went insane; now Mrs. Venable wants Catherine lobotomized to cover up the truth.

The other party is in disarray. Five men vie for the party nomination for president. No one has a majority as the first ballot closes and the front-runners begin to decide how badly they want the job.

After the death of the paranoid emperor Tiberius, Caligula, his heir, seizes power and plunges the empire into a bloody spiral of madness and depravity.