马克和本在十几岁时因同为癌症患者而相识后成为了朋友。20年后，马克成为了一个成功又风流的医生，而本却变得神经质又孤僻，他远离人群，沉浸在自己偏执的行为和古怪的习惯之中。一则戏剧性的新闻颠覆了他们的生活，挑战着两人之间的友谊。为了使本能够走出自己的世界与人交往，马克赌上了他和本所拥有的一切，两人一同卷进了一场将会改变他们生活的冒险中。

35-year-old Morris Bliss is clamped in the jaws of New York City inertia: he wants to travel but has no money, he needs a job but has no prospects, he still shares an apartment with his widowed father, and the premature death of his mother has left him emotionally walled up. When he finds himself wrapped up in an awkward relationship with Stephanie, the 18-year-old daughter of a former classmate, Morris quickly discovers his static life unraveling and opening up in ways that are long overdue.